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SARS-CoV-2 Research: Second possible effective mechanism of remdesivir discovered


Date Time
SARS-CoV-2 Research: Second possible effective mechanism of remdesivir discovered
The virostatic agent remdesivir was developed to disrupt an important step in the propagation of RNA viruses, to which SARS-CoV-2 also belongs: the reproduction of the virus’s own genetic material. This is present as RNA matrices with which the host cell directly produces virus proteins. To accelerate the production of its own proteins, however, RNA viruses cause the RNA matrices to be copied. To do so, they use a specific protein of their own (an RNA polymerase), which is blocked by remdesivir. Strictly speaking, remdesivir does not do this itself, but rather a substance that is synthesized from remdesivir in five steps when remdesivir penetrates a cell. ....

Daniel Merk , Vincent Olieric , Ewgenij Proschak , Martin Schr , Victor Hernandez Olmos , Apirat Chaikuad , Stefan Knapp , Buchmann Institute For Molecular Life Sciences , Institute For Pharmaceutical Chemistry , Goethe University Frankfurt , Professor Stefan Knapp , Pharmaceutical Chemistry , Structural Insights , Remdesivir Metabolite , Molecular Life , டேனியல் மேற்க் , ஸ்டீபன் ந்யாப் , கோதீ பல்கலைக்கழகம் பிராங்க்ஃபர்ட் , ப்ரொஃபெஸர் ஸ்டீபன் ந்யாப் , மருந்து வேதியியல் , மூலக்கூறு வாழ்க்கை ,