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Author summary Why was this study done? Sustained engagement and retention in HIV care is critical for optimal HIV treatment outcomes and reduced HIV transmission. For many people living with HIV, disengagement is inevitable during the long course of HIV treatment. It remains unclear which combination of reengagement strategies are most effective and under what conditions. What did the researchers do and find? Our systematic review identified 37 studies (6 randomized trials and 31 observational studies), 16 of which were conducted in low- and middle-income countries. The majority of randomized trials were assessed as low risk (N = 3) or of some concern (N = 3) regarding the methodological quality. Most cohort studies that had a control condition were also assessed as good quality (N = 7 out of 10). Based on our meta-analysis, reengagement programs were able to return 39% of all patients who were characterized as lost to follow-up, reengagement contact resulted in 58% return among ....