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UIC researchers discover hidden link between cellular defense systems


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IMAGE: UIC medical and Ph.D. student Alex Agelid, left, and Dr. Deepak Shukla, UIC Marion Schenk Professor of Ophthalmology and UIC professor of microbiology and immunology at the College of Medicine..
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Credit: Photo provided by researchers
Researchers at the University of Illinois Chicago have discovered that heparanase, HPSE, a poorly understood protein, is a key regulator of cells innate defense mechanisms.
Innate defense responses are programmed cellular mechanisms that are triggered by various danger signals, which have been conserved in many species throughout evolution. These systems can be set into action by pathogens, such as viruses, bacteria and parasites, as well as by environmental toxins and dysfunctional cells that can accumulate in the body over time. A more thorough understanding of the commonalities and connections between these processes has the potential to generate multi-target therapy against a variety of huma ....

United States , Uppsala Lan , Satvik Hadigal , Deepak Shukla , Rahul Suryawanshi , Anaamika Campeau , Chandrashekhar Patil , Patricia Finn , Benjamin Turturice , Evan Kyzar , Lulia Koujah , Alex Agelidis , David Perkins , Tejabhiram Yadavalli , James Hopkins , Jacob Wozniak , University Of Illinois Chicago , Israel Vlodavsky At Rappaport Institute , National Institutes Of Health , University Of Uppsala , College Of Medicine , Dinesh Jaishankar At Northwestern University , Illinois Chicago , Schenk Professor , Clinical Investigation Insight , Dinesh Jaishankar ,