Data suggest that intermediate clinical endpoints can serve as surrogate endpoints for overall survival in patients with early-stage breast cancer receiving adjuvant therapy.
Dec 15, 2020
MONDAY, Dec. 14, 2020 (HealthDay News) Pregnancy is less likely after prior breast cancer (BC) diagnosis, according to the results of a review presented at the annual San Antonio Breast Cancer Symposium, held virtually from Dec. 8 to 11
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Eva Blondeaux, M.D., from IRCCS Policlinico San Martino Hospital in Genova, Italy, and colleagues conducted a systematic literature review to examine pregnancy after BC, fetal and obstetrical outcomes, disease-free survival (DFS), and overall survival (OS). Data were included from 39 studies with 57,739 women with cancers other than BC and 114,573 women with BC.
The researchers found that 7,505 of the BC patients had a pregnancy after BC diagnosis. BC patients had lower chances of having a pregnancy following anticancer treatment completion compared to women from the general population (relative risk, 0.40). BC survivors had significantly increased risks of low birth weight, small for gestational age, preterm delivery, and cesarea
Breast cancer survivors less likely to get pregnant than the general population
A large meta-analysis of breast cancer survivors of childbearing age indicated that they are less likely than the general public to get pregnant, and they face higher risk of certain complications such as preterm labor. However, most survivors who do get pregnant deliver healthy babies and have no adverse effects on their long-term survival, according to data presented at the 2020 San Antonio Breast Cancer Symposium, held Dec. 8-11.
With the availability of more effective anticancer treatments, survivorship has gained substantial attention. Today, returning to a normal life after cancer diagnosis and treatment should be considered as a crucial ambition in cancer care. In patients diagnosed during their reproductive years, this includes the possibility to complete their family planning.