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Ancient Brazilian genomes may hold the secrets of treponemal evolutionary history

Study reconstructs four ancient treponeme genomes from 2,000-year-old Brazilian remains, revealing their close relation to the bejel-causing Treponema pallidum endemicum and challenging previous hypotheses about treponeme subspecies adaptability. ....

Santa Catarina , United States , National Center , Image Credit , South America , Biotechnology Information , European Nucleotide Archive , Supplementary Table , New World , Antibiotic Resistance ,

Recommendations on data sharing in HIV drug resistance research

Author summary • Human immunodeficiency virus (HIV) drug resistance has implications for antiretroviral treatment strategies and for containing the HIV pandemic because the development of HIV drug resistance leads to the requirement for antiretroviral drugs that may be less effective, less well-tolerated, and more expensive than those used in first-line regimens. • HIV drug resistance studies are designed to determine which HIV mutations are selected by antiretroviral drugs and, in turn, how these mutations affect antiretroviral drug susceptibility and response to future antiretroviral treatment regimens. • Such studies collectively form a vital knowledge base essential for monitoring global HIV drug resistance trends, interpreting HIV genotypic tests, and updating HIV treatment guidelines. • Although HIV drug resistance data are collected in many studies, such data are often not publicly shared, prompting the need to recommend best practices to encourage and st ....

United States , Sherlock Biosciences , Astra Zeneca , National Center , Danaher Corporation , United States Centers For Disease , Centers For Disease , World Health Organization , Data Bank , Janssen Pharmaceuticals , Atea Pharmaceuticals , Shinogi Pharmaceuticals , National Institute Of Allergy , National Institutes Genomic Data Sharing , Gilead Sciences , National Institutes Of Health , Us National Institutes Of Health , Abbott Pharmaceuticals , Creative Commons , National Institute , Infectious Diseases , Merck Sharp , Viiv Healthcare , Delve Bio , Virology Education , World Health ,

Insights from 116 countries reveal disturbingly high rates of antibiotic resistance in Salmonella

GLOBAL - A groundbreaking study harnessing publicly available whole genome sequencing (WGS) data has shed light on the concerning landscape of antimicrobial . ....

United States , Us National Center , European Nucleotide Archive , Biotechnology Information , Pathogen Detection ,