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Clinical trials of tuberculosis vaccines in the era of increased access to preventive antibiotic treatment

Approximately 10·6 million people worldwide develop tuberculosis each year, representing
a failure in epidemic control that is accentuated by the absence of effective vaccines
to prevent infection or disease in adolescents and adults. Without effective vaccines,
tuberculosis prevention has relied on testing for Mycobacterium tuberculosis infection
and treating with antibiotics to prevent progression to tuberculosis disease, known
as tuberculosis preventive treatment (TPT). Novel tuberculosis vaccines are in development
and phase 3 efficacy trials are imminent. ....

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