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Mice with humanized immune systems test new cancer therapeutic approach that blindfolds immune cells to the body's self-recognition system

Researchers investigated the anticancer effects of drugs targeting human tumor-associated macrophages (TAMs) in vivo. In humanized murine models, they tested the effectiveness of an antibody to human signal regulatory protein alpha (SIRPα) for cancer immunotherapy. ....

Lightspring Shutterstock , Anti Inflammatory , Ancer Immunotherapy , Immune System , N Vivo , Tumor Associated Macrophages ,

New radio-theranostics approach shows promise in the fight against pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide, with a 5-year survival rate of less than 10%. Many PDAC tumors in early stage go undetected because they are not found using conventional imaging methods, including fluorodeoxyglucose positron emission tomography (PET) scans. ....

Tadashi Watabe , Lily Ramsey , Kazuya Kabayama , Osaka University , Journal Of Nuclear Medicine , Nuclear Medicine , Monoclonal Antibody , Nuclear Medicine , Pancreatic Cancer , Positron Emission Tomography ,

Researchers explore immunomodulating targets for improving glioblastoma therapies

Researchers have delved into the intricate heterogeneity of glioblastoma, a notoriously aggressive brain tumor, using advanced single-cell RNA sequencing and innovative zebrafish avatars. Their findings spotlighted the LGALS1 gene's role in immunosuppression and suggested potential therapeutic avenues for personalized GBM treatment. ....

Neha Mathur , Neha Mathuroct , Sophia Coveney , Brain Tumor , N Vitro , N Vivo , Ibonucleic Acid ,