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Duke University: New Vaccine Blocks COVID-19 and Variants, Plus Other Coronaviruses


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A potential new vaccine developed by members of the Duke Human Vaccine Institute has proven effective in protecting monkeys and mice from a variety of coronavirus infections including SARS-CoV-2 as well as the original SARS-CoV-1 and related bat coronaviruses that could potentially cause the next pandemic.
The new vaccine, called a pan-coronavirus vaccine, triggers neutralizing antibodies via a nanoparticle. The nanoparticle is composed of the coronavirus part that allows it to bind to the body’s cell receptors, and is formulated with a chemical booster called an adjuvant. Success in primates is highly relevant to humans.
The findings appear Monday, May 10 in the journal Nature. ....

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Duke scientists develop new potential coronavirus vaccine – it's already effective in animal studies


by Sarah Avery May 10, 2021 .
DURHAM – A potential new vaccine developed by members of the Duke Human Vaccine Institute has proven effective in protecting monkeys and mice from a variety of coronavirus infections – including SARS-CoV-2 as well as the original SARS-CoV-1 and related bat coronaviruses that could potentially cause the next pandemic.
The new vaccine, called a pan-coronavirus vaccine, triggers neutralizing antibodies via a nanoparticle. The nanoparticle is composed of the coronavirus part that allows it to bind to the body’s cell receptors, and is formulated with a chemical booster called an adjuvant. Success in primates is highly relevant to humans. ....

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New vaccine blocks COVID-19 and variants, plus other coronaviruses


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DURHAM, N.C. - A potential new vaccine developed by members of the Duke Human Vaccine Institute has proven effective in protecting monkeys and mice from a variety of coronavirus infections including SARS-CoV-2 as well as the original SARS-CoV-1 and related bat coronaviruses that could potentially cause the next pandemic.
The new vaccine, called a pan-coronavirus vaccine, triggers neutralizing antibodies via a nanoparticle. The nanoparticle is composed of the coronavirus part that allows it to bind to the body s cell receptors and is formulated with a chemical booster called an adjuvant. Success in primates is highly relevant to humans. ....

South Africa , State Of North Carolina , North Carolina , United States , United Kingdom , University Of North Carolina , Rachell Spreng , C Todd Demarco , Mahnaz Minai , Surender Khurana , Thomash Oguin , Kartik Manne , Sophie Gobeil , Elizabethw Petzold , S Munir Alam , Matthew Gagne , Markg Lewis , Diann Moore , Hanne Andersen , Fangping Cai , Kevin Saunders , Davidr Martinez , Longpingv Tse , Robertj Edwards , Laural Sutherland , Christopherb Fox ,

Women are the stronger sex in fighting COVID-19 – here's why, says Duke researcher


by Sarah Avery April 15, 2021 .
DURHAM – When it comes to COVID-19, women seem to be the stronger sex, suffering severe disease at about half the rate as men, but the reason for this has been elusive.
Now a chance experiment by an ophthalmology researcher at Duke Health has led to an insight: Women have more of a certain type of immune cell that fights infections in mucosal tissue, and these immune cells amass in the lungs, poised to attack the COVID virus.
“Better armed with these specialized immune cells, women appear to be more equipped to fight some of the most severe impacts of COVID-19, notably the respiratory infections that can become life-threatening,” said Daniel Saban, Ph.D., an associate professor in Duke’s Department of Ophthalmology and in the Department of Immunology. ....

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