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Research reveals a differential clinical response to pembrolizumab in uterine cancer patients

New research from Yale Cancer Center reveals for the first time ever a differential clinical response to pembrolizumab in Lynch-like (mutated) vs methylated microsatellite instability-high (MSI-H) uterine cancer patients, increasing our understanding about the proportion of patients that derive benefit from immune checkpoint blockade. ....

Elena Bonazzoli , Akiko Iwasaki , Bryan Chow , Stefania Bellone , Alessandro Santin , Tai Michaels , Emily Henderson , Gilead Sciences , National Institutes Of Health , Yale Cancer Center , Lab Diagnostics Automation , Cancer Foundation , Merck Co , Lab Diagnostics Automation Industry , Study Co , Eric Song , Automation Industry Focus , National Institutes , Endometrial Cancer , Uterine Cancer ,

Researchers identify genes behind uterine leiomyosarcoma

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New Haven, Conn. In a new study, Yale Cancer Center researchers have defined the genetic landscape of uterine leiomyosarcomas (uLMS). Furthermore, using fully sequenced patient-derived xenografts, the team has preclinically validated new treatment modalities, which may point to new treatments for uterine cancer. Study results were published online in an early edition of the
Proceedings of the National Academy of Science (PNAS).
Uterine cancer is the most common gynecologic malignancy and uterine leiomyosarcomas (uLMS) are highly lethal sarcomas arising from the myometrium, the smooth muscle layer of the uterus. They represent the most common type of uterine sarcomas, which overall account for three to seven percent of all uterine cancers. uLMS have poor prognosis and are characterized by aggressive biological behavior leading to early local and distant metastatic spread. ....

United States , South Korea , Laura Ardighieri , Marcin Imielinski , Masoud Azodi , Xiaotong Yao , Aditya Deshpande , Elena Bonazzoli , Petere Schwartz , Weilai Dong , Aranzazu Manzano , Chiara Romani , Sergio Pecorelli , Glorias Huang , Joseph Schlessinger , Antonella Ravaggi , Eliana Bignotti , Mitchell Clark , Pei Hui , Joanr Tymon Rosario , Kaya Bilguvar , Burak Zeybek , Barbara Gnutti , Luca Zammataro , Samir Zaidi , Williamh Prusoff ,