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Argentina confirms monkeypox case - Outbreak News Today

Argentina confirms monkeypox case - Outbreak News Today
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Middle East respiratory syndrome coronavirus vaccine based on a propagation-defective RNA replicon elicited sterilizing immunity in mice

Coronaviruses (CoVs) have the largest genome among RNA viruses and a proofreading exoribonuclease (nsp14) responsible for high-fidelity RNA synthesis. These properties make CoVs very attractive for the establishment of vaccine platforms or viral vectors since they can stably store large amounts of information without genome integration. Using Middle East respiratory syndrome coronavirus (MERS-CoV) as a model, a propagation-deficient RNA replicon was generated by removing the envelope (E) gene (essential for viral morphogenesis and involved in virulence) and accessory genes 3, 4a, 4b, and 5 (responsible for antagonism of the innate immune response): MERS-CoV-Δ[3,4a,4b,5,E]. This replicon is strongly attenuated and elicits sterilizing protection after a single immunization, making it a promising vaccine candidate and an interesting platform for vector-based vaccine development. ....

Jouy En Josas , France General , Baden Wüberg , Noord Holland , Universiteit Van , Severo Ochoa , Paul Mccray , Environmental Council Of Madrid , University Of Iowa , Miltenyi Biotec Inc , International European Union Guideline , Spanish National Royal Decree , Histology Service , Electron Microscopy Service Of Centro De Biolog , Mac Graphpad Software , California Institute Of Technology , Ethical Committee Of Centro De Investigaci , Spanish National Law , University Of Heidelberg , Middle East , West Nile , Environmental Council , Ethical Committee , Centro De Investigaci , Sanidad Animal , Instituto Nacional De Investigaci ,