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UTSW discovers protective 'acid wall' formed by cancer cells

Cancer cells release a significantly more concentrated level of acid than previously known, forming an “acid wall” that could deter immune cells from attack ....

United States , Ralph Deberardinis , Zachary Bennett , Anthony Grichuk , Eugenep Frenkel , Mingyi Chen , Qiang Feng , John Dowling Mcconnell , Elaine Dewey Sammons , Raymundo Pantoja , David Andrew Pistenmaa , Jinming Gao , Joelb Steinberg , Investigator Of The Howard Hughes Medical Institute , Drug Administration , Sowell Family Scholar In Medical Research , National Cancer Institute Center Support Grant , Onconano Medicine Inc , Simmons Cancer Center , Cancer Research , Southwestern Medical Center , National Institutes Of Health , Haroldc Simmons Comprehensive Cancer Center , Division Of Pediatric Genetics , Eugene Mcdermott Center , Research Institute Of Texas ,

Lactate may have a previously unrecognized role in fighting cancer

A new study by UT Southwestern's Simmons Cancer Center scientists suggests that lactate, a metabolic byproduct produced by cells during strenuous exercise, can rejuvenate immune cells that fight cancer. ....

Bo Li , Jinming Gao , Mary Nell , Zhichen Sun , Emily Henderson , John Dowling Mcconnell , Jiahui Chen , Peter Odonnell Jr , Xuexin Yu , Suxin Li , Jian Wang , Wei Li , Ralphb Rogers , Qiang Feng , Tongyi Huang , Eugenep Frenkel , David Andrew Pistenmaa , Zhida Liu , Jonathan Wilhelm , Elaine Dewey Sammons , Nature Communications , National Institutes Of Health , Haroldc Simmons Comprehensive Cancer Center , Ut Southwestern Simmons Cancer Center , Lyda Hill Department Of Bioinformatics , Simmons Cancer Center ,

STINGing tumors with nanoparticles

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IMAGE: This artist s rendering shows a synthetic polymer (purple) that activates STING proteins (yellow and green motifs) for cancer immunotherapy.
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Credit: Shenyang Zhiyan Science and Technology Co. Ltd.
DALLAS - Feb. 8, 2021 - A new nanoparticle-based drug can boost the body s innate immune system and make it more effective at fighting off tumors, researchers at UT Southwestern have shown. Their study, published in
Nature Biomedical Engineering, is the first to successfully target the immune molecule STING with nanoparticles about one millionth the size of a soccer ball that can switch on/off immune activity in response to their physiological environment. ....

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