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Birtamimab Pushes the Needle in AL Amyloidosis

Findings from an analysis of treatment patterns for patients with systemic amyloid light chain amyloidosis have demonstrated that several unmet needs exist, including timely diagnosis and limited survival outcomes for patients with advanced disease. ....

United States , Moriea Gertz , Debakey Cardiovasc , Efstathios Kastritis , Vaishali Sanchorawala , American Society Of Hematology Annual Meeting , Kapodistrian University Of Athens , Mayo Clinic Comprehensive Cancer Center , Staging Criteria , Autologous Stem Cell Transplantation Program , Boston Medical Center , Mayo Stage , American Society , Hematology Annual Meeting , Kapodistrian University , Patients With Systemic Amyloid Light Chain Amyloidosis , Vital Study , Affirm Al Trial , National And Kapodistrian University Of Athens ,

Dr Kastritis on the Investigation of Birtamimab in Mayo Stage IV AL Amyloidosis

Efstathios Kastritis, MD, discusses the background of birtamimab and the rationale for investigating the agent in combination with standard-of-care chemotherapy in newly diagnosed patients with Mayo Stage IV amyloid light chain amyloidosis in the phase 3 AFFIRM-AL trial.
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Efstathios Kastritis , Division Of Clinical Therapeutics , University Of Athens School Medicine , Clinical Therapeutics , Athens School , Mayo Stage , Onclive Tv ,

Development of Autoantibodies after mild COVID-19 infection

These antibodies can also have a “toxic” effect on normal tissues and organs, that is, they act as “autoantibodies”. ....

Los Angeles , Efstathios Kastritis , Kapodistrian University Of Athens , Translational Medicine , Therapeutic Clinic , Medical School , Kapodistrian University , Thanos Dimopoulos ,

Development of Autoantibodies after mild COVID-19 infection

These antibodies can also have a “toxic” effect on normal tissues and organs, that is, they act as “autoantibodies”. ....

Los Angeles , Efstathios Kastritis , Kapodistrian University Of Athens , Translational Medicine , Therapeutic Clinic , Medical School , Kapodistrian University , Thanos Dimopoulos ,

Janssen: Updated Data Demonstrate Significant Improvement in Haematologic Complete Response with DARZALEX? (daratumumab) Subcutaneous (SC) Formulation in Patients with Newly Diagnosed Light Chain (AL) Amyloidosis

Further analysis from the Phase 3 ANDROMEDA study presented at the 2021 ASCO Annual Meeting also show doubling rates of organ response with no new safety signals The Janssen Pharmaceutical Companies ....

United States , Christopher Delorefice , Velcade Melphalan , Daratumumab Bortezomib , Efstathios Kastritis , Bortezomib Melphalan , Jennifer Mcintyre , Noah Reymond , Velcade Bortezomib Melphalan , Edmond Chan , Janssen Biotech Inc , American Society Of Clinical Oncology , European Hematology Association , Janssen Research Development , Janssen Pharmaceutical Companies , Janssen Pharmaceutical Companies Of Johnson , Kapodistrian University Of Athens School Medicine , Janssen Cilag Ltd , European Union , Amyloidosis Research Consortium , National Library Of Medicine , Committee For Medicinal Products Human Use , European Myeloma Network , None Of The Janssen Pharmaceutical Companies , National Organization For Rare Disorders , European Commission ,