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Cancer, the Emperor of All Maladies as it has been termed, has been studied for millennia. President Nixon s War on Cancer resulted in slow but steady progress, aided by the biotechnology revolution, the development of monoclonal antibodies (
see Herceptin®) and more recent developments in immunological interventions like CAR-T cells (
But the basis for many characteristics of cancer biology remain elusive, including what is classically termed the Warburg effect,
i.e., the tendency of cancer cells to be dependent upon aerobic glycolysis instead of oxidative phosphorylation even in the presence of oxygen and thus not being an adaptation for low oxygen conditions as it is in normal cells. (Those with long memories will remember the saga of the eminent Efraim Racker being fooled by a graduate student who presented falsified evidence of a protein kinase cascade that regulated glycolysis.) This effect has been kn