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How to Get Rid of Sciatica Pain: Solutions from Back Experts Amy Marturana Winderl The scoop on sciatica pain Fun fact: The sciatic nerve is the largest nerve in the human body. It runs from the lower back down each side of your body, along the back of the hips, butt cheeks, and knees, down the back of the calf, and into the foot. It provides both sensory and motor nerve function to the legs and feet. Not-so-fun fact: Sometimes this nerve can get compressed in the spine at one of the roots where it branches off the spinal cord and cause pain that radiates down the length of the nerve. This is a dreaded condition known as sciatica. It is estimated that between 10 and 40 percent of people will experience sciatica in their lifetime. ....