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Prescription drugs are the leading cause of death

Prescription drugs are the leading cause of death
sott.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sott.net Daily Mail and Mail on Sunday newspapers.

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Perinatal morbidity among women with a previous caesarean delivery (PRISMA trial): a cluster-randomised trial

Perinatal morbidity among women with a previous caesarean delivery (PRISMA trial): a cluster-randomised trial
thelancet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thelancet.com Daily Mail and Mail on Sunday newspapers.

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From target discovery to clinical drug development with human genetics

The substantial investments in human genetics and genomics made over the past three decades were anticipated to result in many innovative therapies. Here we investigate the extent to which these expectations have been met, excluding cancer treatments. In our search, we identified 40 germline genetic observations that led directly to new targets and subsequently to novel approved therapies for 36 rare and 4 common conditions. The median time between genetic target discovery and drug approval was 25 years. Most of the genetically driven therapies for rare diseases compensate for disease-causing loss-of-function mutations. The therapies approved for common conditions are all inhibitors designed to pharmacologically mimic the natural, disease-protective effects of rare loss-of-function variants. Large biobank-based genetic studies have the power to identify and validate a large number of new drug targets. Genetics can also assist in the clinical development phase of drugs—for example ....

San Francisco , United States , Southwest Finland , Van Goor , Lopes Alves , Davey Smith , Nguengang Wakap , Finasteride Male Pattern Hair Loss Study Group , Finasteride Study Group , Precision Medicine Initiative All Of Us , Health Drug , Estonian Genome Center , American Heart Association , Collaborative Group , Human Services , Us Department Of Health , Disease Diagnosis In Health Care , University Of Tartu , Wellcome Trust Case Control Consortium , Africa Consortium , Development Study , Regeneron Genetics Center , European Medicines Agency , Genomics Beyond Health Government Office For Science , Drug Discov , Human Genome ,

World Health Organization Vaccine Recommendations: Scientific Flaws, or Criminal Misconduct?

Editors Note: ( Ralph Turchiano) The following is from the expert witness Marc Girard, M.D., M.Sc against the alleged vaccine conspiracy and criminal inquiry against the World Health Organization (WHO). At the time of this printing most of the documentation from those court proceedings were secret, and sealed by court order. PDF of the Original… ....

United States , P Van Damme , Ralph Turchiano , Briets Bernard Vallat , Marc Girard , Le Taillanter , Van Damme , French Centers For Disease , Sciences Et Avenir , Carnalld Shire Hall Communications , Kanem Proceedings Of The International Congress , Antwerp University It , European Experts Of The World Health Organization , Ressp International , Community Health Risk , World Health Organization , Health Econ , Us Centers For Disease , Editors Note , American Physicians , Surgeons Volume , Direction General De La Sant , French Centers , Disease Control , Viral Hepatitis Prevention Board , Action Toward Control ,

Prenatal Development Not Impacted by ADHD Medication Use, Study Finds

Prenatal development neurodevelopment and physical growth was not impacted by ADHD medication use in this long-term register study comparing exposed and unexposed children. ....

United States , Women Mental Health , National Vital Statistics , Postnatal Exposure , Drug Saf , Attention Disorders , Vital Statistics Reports ,