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Cobolimab/Dostarlimab Combination Shows Initial Efficacy and Safety Signals in Advanced NSCLC

The anti-TIM3 monoclonal antibody, cobolimab utilized in combination with the anti-PD–1 antibody dostarlimab-gxly demonstrated promising signs of clinical activity and an acceptable safety profile across all dose levels in heavily pretreated patients with advanced/metastatic non–small cell lung cancer. ....

United States , Diwakar Davar , Department Of Hematology Oncology Medical , University Of Pittsburgh Medical Center , Hillman Cancer Center , Medical Oncology , Pittsburgh Medical Center , Cancer Center , Proportion Score , Cobolimab , Dostarlimab Gxly , Phase 1 Amber Trial Nct02817633 ,

Subgroup Analysis Shows Consistent Benefit for Dostarlimab Plus Chemo in Nonsquamous in NSCLC

Overall response rates were similar across subgroups of patients with nonsquamous non–small cell lung cancer for the combinations of dostarlimab-gxly plus chemotherapy and pembrolizumab plus chemotherapy, and responses numerically favored the dostarlimab-based combination in most subgroups, according to a subgroup analysis of the phase 2 PERLA trial. ....

Ortega Granados , Laura Ortega Granados , European Lung Cancer Congress , University Hospital Of Ja , Lung Cancer , Medical Oncology Unit , University Hospital , Lung Cancer Congress , Nonsquamous Non Small Cell Lung Cancer , Dostarlimab Gxly , 2023 European Lung Cancer Congress , Phase 2 Perla Trial Nct04581824 ,