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Announcing 2024 FASEB Excellence in Science Awards

The Federation of American Societies for Experimental Biology (FASEB) bestows its highest honor, FASEB Excellence in Science Awards, to three women scientists. ....

San Francisco , United States , Pilar Alcaide , Hollya Ingraham , Holly Ingraham , Dmary Ann Bjornsti , Joanng Wellner , Mariana Xavier Byndloss , American Association Of Immunologists , Department Of Molecular , Mineral Research , National Institutes Of Health , Pamerican Society For Bone , University Of Alabama At Birmingham , Tufts University School Of Medicine , Vanderbilt University Medical Center , Federation Of American Societies For Experimental Biology , Immunology At Vanderbilt University Medical Center , Department Of Pharmacology , Immunology Graduate Program , American Physiological Society , University Of California , Vanderbilt Institute For Infection , American Society For Investigative Pathology , Endocrine Society , American Societies ,

FASEB Announces Partnership with Dryad

The Federation of American Societies for Experimental Biology (FASEB), the largest coalition of biomedical research associations in the United States, announces ....

United States , Dmary Ann Bjornsti , Jennifer Gibson , Federation Of American Societies For Experimental Biology , University Of Alabama At Birmingham , Department Of Pharmacology , American Societies , Experimental Biology ,

FASEB Announces Partnership with Dryad

The Federation of American Societies for Experimental Biology (FASEB), the largest coalition of biomedical research associations in the United States, announces ....

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Bjornsti begins her term as president of FASEB

FASEB is the largest coalition of biological and biomedical research associations in the United States and advocates for basic biomedical research. Mary-Ann Bjornsti, Ph.D.Mary-Ann Bjornsti, Ph.D., professor and former c. ....

United States , National Institutes Of Health , Dmary Ann Bjornsti , Dmary Ann Bjornsti , American Society For Biochemistry , Marnixe Heersink School Of Medicine , Translational Research , Oneal Comprehensive Cancer Center , American Society For Pharmacology , University Of Alabama At Birmingham , Genetics Society Of America , Federation Of American Societies For Experimental Biology , Department Of Pharmacology , Ann Bjornsti , American Societies , Experimental Biology , Clinical Pharmacology , O Neal Comprehensive Cancer Center , National Institutes , Science Policy , American Society , Molecular Biology , Genetics Society , Health Care , Economic Development ,

Understanding Topotecan's Cancer Inhibiting Power

Topotecan, a cancer inhibitor, interacts with an important protein (TopoIB), causing a (cancer) cell to malfunction. The TopoIB protein is responsible for the removal of loops from DNA, which arise amongst other things during cell division.
The TopoIB protein binds to the DNA molecule, clamps around it and cuts one of the two DNA strands, after which it allows it to unwind and finally joins the broken ends together.
Until now it has been supposed that topotecan only causes the TopoIB protein to reside longer than normal on the DNA molecule, disturbing the cell division and damaging the (cancer) cell. But the researchers at the University of Delft have now discovered that adding topotecan also dramatically impedes the unwinding and that DNA loops accumulate as a result. The accumulation of these DNA loops forms the basis for an alternative mechanism, and could help in the development of better cancer medicine. ....

Nynke Dekker , Komaraiah Palle , Daniel Koster , Daniela Koster , Jude Children Research Hospital Memphis United States , University Of Delft , Kavli Institute Of Nanoscience Delft , Elisa Bot , Molecular Biophysics , Kavli Institute , Nanoscience Delft , Jude Children , Research Hospital Memphis , United States , Dmary Ann Bjornsti , டேனியல் கோஸ்டர் , டேனீலா கோஸ்டர் , ஜூட் குழந்தைகள் ஆராய்ச்சி மருத்துவமனை மெம்பிஸ் ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் டெல்ஃப்ட் , கவிளி நிறுவனம் ஆஃப் நானோ அறிவியல் டெல்ஃப்ட் , எலிசா போட் , மூலக்கூறு உயிர் இயற்பியல் , கவிளி நிறுவனம் , நானோ அறிவியல் டெல்ஃப்ட் , ஜூட் குழந்தைகள் , ஆராய்ச்சி மருத்துவமனை மெம்பிஸ் ,