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Optimized nano-micelles can induce efficient genome editing in the mouse brain


Optimized nano-micelles can induce efficient genome editing in the mouse brain
Mar 12 2021
The research group of Deputy Principal Research Scientist Dr. Satoshi Uchida (Associate Professor, Kyoto Prefectural University of Medicine) at the Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki-Japan, Abbreviation: iCONM) reported that optimized nano-micelles can induce efficient genome editing in the mouse brain.
The 2020 Chemistry Nobel Prize-winning technology CRISPR/Cas9 holds great promise for treating various diseases such as congenital disorders and viral infections, by correcting the disease-specific genomic sequences.
This technology attracted increasing attention in the last decade as it allows easy targeting of genomic sequences with high precision and low level of undesired off-target gene editing. However, safe and efficient delivery of the Cas9 DNA cutting enzyme and guide RNA (gRNA), which is a short piece of RN ....

Saed Abbasi , Kazunori Kataoka , Kyoto Prefectural University Of Medicine , Innovation Center , Deputy Principal Research Scientist Dr , Deputy Principal Research Scientist , Satoshi Uchida , Associate Professor , Kyoto Prefectural University , Director General , Nobel Prize Winning , Genome Editing , கியோட்டோ ப்ரிஃபெக்சரல் பல்கலைக்கழகம் ஆஃப் மருந்து , கண்டுபிடிப்பு மையம் , துணை ப்ரிந்ஸிபல் ஆராய்ச்சி விஞ்ஞானி டாக்டர் , துணை ப்ரிந்ஸிபல் ஆராய்ச்சி விஞ்ஞானி , சதோஷி உசிதா , இணை ப்ரொஃபெஸர் , கியோட்டோ ப்ரிஃபெக்சரல் பல்கலைக்கழகம் , இயக்குனர் ஜநரல் , நோபல் ப்ரைஸ் வென்றது , மரபணு திருத்துதல் ,