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IMAGE: After radiosurgery concurrent with nivolumab in 59-year-old patient with melanoma BM (patient 1; Supplemental Tables 3 and 5), F-18 FET PET at follow-up 12 weeks after treatment initiation (bottom row). view more
Credit: Image created by N. Galldiks et al., Research Center Juelich, Juelich, Germany.
Reston, VA For patients with brain metastases, amino acid positron emission tomography (PET) can provide valuable information about the effectiveness of state-of-the-art treatments. When treatment monitoring with contrast-enhanced magnetic resonance imaging (MRI) is unclear, adding 18F-FET PET can help to accurately diagnose recurring brain metastases and reliably assess patient response. This research was published in The
Journal of Nuclear Medicine.
New model may explain the perplexing asymmetrical motor symptoms in Parkinson s disease
Parkinson s disease (PD) is characterized by slowness of movement and tremors, which often appear asymmetrically in patients. The new model of PD described in this review article published in the
Journal of Parkinson s Disease may explain these perplexing asymmetrical motor symptoms and other known variations such as different degrees of constipation and sleep disorders.
PD is a heterogenous disorder. Symptoms and the speed with which symptoms progress vary greatly among patients. In three-quarters of patients, motor symptoms initially appear in one side of the body. Some patients develop constipation, loss of smell, sleep disorders, and other symptoms several years before diagnosis, but others do not. Although it is possible to define several subtypes of PD characterized by similar constellations of symptoms, the underlying causes of these differences are poorly understood. Aggregation and ne
The characteristic slowness of movement and tremors that are characteristic of Parkinson’s disease (PD) often appear asymmetrically in patients. A new model of PD, published in the
Symptoms and the speed with which they progress vary greatly among patients. In many patients, motor symptoms initially appear in one side of the body. Some patients develop constipation, loss of smell, sleep disorders, and other symptoms several years before diagnosis, but others do not.
Although it is possible to define several subtypes of PD characterized by similar constellations of symptoms, the underlying causes of these differences are poorly understood. Aggregation and neuron-to-neuron spread of the protein alpha-synuclein is thought to be involved.
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IMAGE: A) Schematic representation of important connectome details in Parkinson s disease (PD). B) Brain-first PD: the asymmetric distribution of alpha-synuclein persists into later disease stages. C) Body-first PD: the symmetric alpha-synuclein. view more
Credit: Journal of Parkinson s Disease.
Amsterdam, April 28, 2021 - Parkinson s disease (PD) is characterized by slowness of movement and tremors, which often appear asymmetrically in patients. The new model of PD described in this review article published in the
Journal of Parkinson s Disease may explain these perplexing asymmetrical motor symptoms and other known variations such as different degrees of constipation and sleep disorders.
PD is a heterogenous disorder. Symptoms and the speed with which symptoms progress vary greatly among patients. In three-quarters of patients, motor symptoms initially appear in one side of the body. Some patients develop constipation, loss of smell, sleep disorders, and o
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