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Structure of a Bacterial "Drug Pump" Reveals New Way to Counter Hospital-borne Infection

/PRNewswire/ By revealing the structure of a protein used by bacteria to pump out antibiotics, a research team designed an early-stage therapeutic that. ....

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Understanding Crystallisation: Faraday Discussion

Understanding Crystallisation: Faraday Discussion
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Prototype Shows Promise As Approach to Countering Pancreatic Cancer

Prototype Shows Promise As Approach to Countering Pancreatic Cancer
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NEW YORK, May 11, 2021 /PRNewswire/ A research team has designed a molecule with potential to interfere in a new way with altered proteins that cause abnormal growth in 35 percent of pancreatic cancers.
Published online in
Nature Communications on May 11, a new study found that a molecule called a monobody clings to cancer-causing versions of the KRAS protein and keeps them from transmitting their signals. Changes in the DNA of the
KRAS gene – which encodes a molecular switch that toggles between active and inactive states to regulate growth – cause the related protein to become stuck in the on mode. Cells with such mutations continually multiply and give rise to cancer. ....

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Chemistry professor receives National Science Foundation CAREER Award

Beth Elacqua, assistant professor of chemistry.
Image: Penn State
Chemistry professor receives National Science Foundation CAREER Award
Maria Landschoot
January 28, 2021
UNIVERSITY PARK, PA. Beth Elacqua, assistant professor of chemistry, has been honored with a Faculty Early Career Development (CAREER) award from the National Science Foundation (NSF) in recognition of her work on the “synthesis of polymer-based nanoreactors to investigate homogeneous dual catalysis under confinement.”
These nanoreactors can be thought of like simplified models of nature’s polymers, wherein the precise shapes and nano-sizes enable chemical reactions to take place in small, confined areas in an efficient manner.
The CAREER award is the NSF s most prestigious award in support of early-career faculty who have the potential to serve as academic role models in research and education and to lead advances in the mission of their department or organization. The CAREER a ....

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