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Unlocking the secret soldiers: How dendritic cells could revolutionize cancer immunotherapy

A recent review in the journal Immunity delves into the crucial role of dendritic cells (DCs) in shaping T-cell responses in cancer, highlighting their importance in both priming anti-tumor immunity and in ongoing immune interactions within tumors. The findings underscore the potential of DCs as key targets for next-generation cancer immunotherapies. ....

Juan Gaertner , Tensin Homolog , Dendritic Cell Specific Intercellular , Grabbing Non Integrin , C Type Lectin Domain Family , Typei Interferon , Lymph Nodes , Isocitrate Dehydrogenase , Vascular Endothelial Growth Factor , Fms Like Tyrosine Kinase , Ancer Immunotherapy , Immune Response , Immune System , Lymph Nodes , T Cell ,

Glycan switch may explain why SARS-CoV-2 causes such variable symptoms


Glycan switch may explain why SARS-CoV-2 causes such variable symptoms
Researchers in Portugal have provided evidence that might explain why infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes mild or even asymptomatic illness in some individuals, but severe coronavirus disease 2019 (COVID-19) in others.
Salome Pinho from the University of Porto and colleagues showed that circulating T cells exhibit a specific “glycan switch” following infection with SARS-CoV-2 and that this switch is more pronounced in asymptomatic versus symptomatic individuals.
The researchers say this change in the T cell glycosylation profile appears to be triggered by a serum inflammatory factor, the identification of which could lead to a potential new biomarker and therapeutic target. ....

Salome Pinho , Sally Robertson , University Of Porto , Dendritic Cell Specific Intercellular , Grabbing Non Integrin , Image Credit , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Dendritic Cell , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , சலோம் பின்ஹோ , சாலி ராபர்ட்சன் , பல்கலைக்கழகம் ஆஃப் போர்டோ , படம் கடன் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,