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In one of the largest studies of its kind, researchers provide answers to whether COVID-19 vaccinations reduce sickness and mortality following infection with SARS-CoV-2. The study published today in The Lancet Microbe found among individuals recently infected with SARS-CoV-2, those who were fully vaccinated had lower concentrations of almost all inflammation markers (cytokines and chemokines) than those who were unvaccinated in the short-term and long-term after symptomatic SARS-CoV-2 infection. While vaccinations don’t entirely prevent infection, this study demonstrates that vaccination significantly reduces morbidity and mortality by significantly reducing elevated levels of cytokines and chemokines that are correlated with a higher risk of severe infection. “Our research demonstrates the long-term benefits of the COVID-19 vaccines to reduce inflammation even after a breakthrough infection,” said co-author Alison Abraham, PhD, MS, MHS, associate professor of epidemiology

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