Throughout recorded history, people have used substances to relieve suffering and change their moods. Every society has struggled with Substance Abuse and addiction. Of their power, drugs were entrusted to priests or doctors or controlled by law. In the last 20 years, there has been a rapid increase in the amount of drug use and the variety of drugs available. Today, every part of society young, rich and poor, old, families, schools, and at work. Drug abuse is a Public Health issue, which we cant ignore. The National Institute on drug abuse is part of the oklahoma drug abuse and Mental Health administration. It is the legion agency for drug abuse research. We have been asked to bring the best tools in Scientific Investigation to address critical questions about drug abuse and addiction. We need to know what causes drug abuse, how do we treat it, and most important, how do we prevent it. We need cooperation from scientists around the world to attack the problems associated with drug abu