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Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR)

Objective To investigate the effectiveness of combining mirtazapine with serotonin-noradrenaline reuptake inhibitor (SNRI) or selective serotonin reuptake inhibitor (SSRI) antidepressants for treatment resistant depression in primary care.

Design Two parallel group multicentre phase III randomised placebo controlled trial.

Setting 106 general practices in four UK sites; Bristol, Exeter, Hull, and Keele/North Staffs, August 2013 to October 2015.

Participants 480 adults aged 18 or more years who scored 14 or more on the Beck depression inventory, second revision, fulfilled ICD-10 (international classification of diseases, 10th revision) criteria for depression, and had used an SSRI or SNRI for at least six weeks but were still depressed. 241 were randomised to mirtazapine and 239 to placebo, both given in addition to usual SSRI or SNRI treatment. Participants were stratified by centre and minimised by baseline Beck depression inventory score, sex, and current psychol ....

United Kingdom , Caroline Jenkinson , Mary Carter , Ianm Anderson , Dalan Montgomery , Marie Platt , Davids Kessler , Stephaniej Macneill , William Hollingworth , Simon Davies , John Campbell , Sue Jones , Una Macleod , Glyn Lewis , Tom Shepherd , Timj Peters , Helen Gibson , Alison Burns , Deborah Tallon , Simon Gilbody , Chrism Dickens , Ellie Kingsland , National Institute For Health Research , National Health Service , Health Technology Assessment , Biomedical Research Centre At University Hospitals Bristol ,

Después de casi tres años de cárcel en China, dos canadienses regresan a casa

Después de casi tres años de cárcel en China, dos canadienses regresan a casa
ici.radio-canada.ca - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ici.radio-canada.ca Daily Mail and Mail on Sunday newspapers.

New York , United States , United Kingdom , British Columbia , North Korea , Benn Nelms Meng Wanzhou , Davids Kessler , Mikhail Kovrig , Justin Tang , Dominic Barton , Joe Biden , Meng Wanzhou , Colin Robertson , Justin Trudeau , Mikhail Spavor , Court Americans , A Court , After Meng , Chinese Huawei , Columbia Briton , Government Of China , Justin Tang The , August Chinese , Chinese President Xi Jinping , Prime Minister , District East ,

A partir del 20 de septiembre ofrecerán en EU el tercer refuerzo de vacuna contra el Covid-19

A partir del 20 de septiembre ofrecerán en EU el tercer refuerzo de vacuna contra el Covid-19
rancherita.com.mx - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from rancherita.com.mx Daily Mail and Mail on Sunday newspapers.

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Tiempo de duelo - El Liberal

Tiempo de duelo - El Liberal
elliberal.com.ar - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elliberal.com.ar Daily Mail and Mail on Sunday newspapers.

Davids Kessler , Medical Switzerland ,

Los mapas y la búsqueda de nuevos sentidos

Los mapas y la búsqueda de nuevos sentidos
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United States , Davids Kessler , Carina Novarese , ஒன்றுபட்டது மாநிலங்களில் ,