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La Brea Series Finale: NBC Show Cleared Hurdles for Epic End – IndieWire

"La Brea" creator David Appelbaum and director David M. Barrett discuss rising to the challenge of creating a great series finale. ....

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Single-Cell Analysis Reveals Clues About Promising Cancer Therapy

A type of cancer treatment known as CAR T therapy has shown great promise for blood cancer treatments in the last decade, but too often, patients relapse within a short time. Now, a team of researchers has uncovered some critical clues about why – potentially leading to treatments to prevent these relapses. ....

Yanxiang Deng , Stefan Lundh , Stephan Grupp , Davidm Barrett , Ziran Zhao , Kiya Govek , Dongjoo Kim , Zhiliang Bai , Steven Woodhouse , Rahul Arya , J Joseph Melenhorst , Hongxing Sun , Reginam Myers , Yang Xiao , Alev Baysoy , Pablog Camara , Yale University , Yale School Of Medicine , Laboratory Medicine , University Of Pennsylvania , Rong Fan , Yale School , Joseph Melenhorst , Carl June ,

Morning Briefing: Local experts say plenty of blame for Afghanistan; Murder trial marks return to court; Eagles welcome old mates now with Patriots

Good Morning. Here are some of the top stories from around the region. ....

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Creating a safe CAR T-Cell therapy to fight solid tumors in children

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Chimeric Antigen Receptor T-cell therapy CAR T has revolutionized leukemia treatment. Unfortunately, the therapy has not been effective for treating solid tumors including childhood cancers such as neuroblastoma. Preclinical studies using certain CAR T against neuroblastoma revealed toxic effects. Now, a group of scientists at Children s Hospital Los Angeles have developed a modified version of CAR T that shows promise in targeting neuroblastoma, spares healthy brain tissue and more effectively kills cancer cells. Their study was published today in
Nature Communications. While this work is in the preclinical phase, it reveals potential for lifesaving treatment in children and adults with solid tumors. ....

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