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What causes long COVID? Case builds for rogue antibodies

Study finds that antibodies from people with the debilitating condition trigger similar symptoms in mice. Study finds that antibodies from people with the debilitating condition trigger similar symptoms in mice. ....

South Africa , United States , Western Cape , New York , Noord Holland , City Of , United Kingdom , Peter Openshaw , David Putrino , Resia Pretorius , Danny Altmann , Davide Robbiani , Niels Eijkelkamp , Imperial College London , Institute For Research , Stellenbosch University , University Medical Center Utrecht , Kateryna Kon Science Photo Library , Icahn School Of Medicine At Mount Sinai , Amsterdam University Medical Center , Science Photo , Amsterdam University Medical , Icahn School , Mount Sinai , New York City ,

'Good autoantibodies' associated with a milder course and lower risk of long Covid

Sometimes in the laboratory there are unexpected results. "Previously it had been observed that autoantibodies are common in severe Covid patients, those who end up in intensive care," says Jonathan Muri, postdoctoral fellow at the Institute for Research in Biomedicine (IRB, affiliated with the Università della Svizzera italiana) and co-author of the study. ....

United States , Trentino Alto Adige , United Kingdom , Jonathan Muri , Ospedaliero Cantonale , Davide Robbiani , Mariagrazia Uguccioni , Valentina Cecchinato , Emily Henderson , Moncucco Hospital Group , Humanitas University , Institute For Research , Humanitas Research Hospital , Industry Focus , Nature Immunology , Ente Ospedaliero Cantonale , Covid 19 , Immune System ,

Broad Range Antibodies Neutralize All SARS-CoV-2 Variants and Other Coronaviruses

Coldspot-guided method identified antibodies against highly conserved SARS-CoV-2 epitopes that recognize all variants and other coronaviruses. ....

Davide Robbiani , Filippo Bianchini , Institute For Research , Science Immunology , Virginia Crivelli ,

Researchers discover antibodies that recognize all SARS-CoV-2 variants

Some portions of the infamous coronavirus spike remained unchanged among variants, enabling certain rare antibodies to recognize all SARS-CoV-2 variants. ....

Elissa Wolfson , Davide Robbiani , Scientists At Switzerland Institute For Research , Science Advisory Board , Science Immunology , Coronavirus Spike , Coronavirus Sequences , Oronavirus Coldspots , Monoclonal Antibodies , Sars Cov 2 Variants , Accine Immunogens , Viral Evolution , Oldspot Guided Antibody Discovery , Antibody Discovery , Irus Spike Glycoprotein , Uman Neutralizing Antibodies , Neutralizing Antibodies , Iral Epitopes , Fusion Peptide , Roteolytic Cleavage , Humanized Mice , Bispecific Antibodies , Ngiotensin Converting Enzyme 2 , Institute For Research In Biomedicine ,

Second-generation double antibody protects from SARS-CoV-2 and its tested variants

Second-generation double antibody protects from SARS-CoV-2 and its tested variants
The Institute for Research in Biomedicine (IRB; Bellinzona, Switzerland), affiliated to the Università della Svizzera italiana (USI) developed a second-generation double antibody that protects from SARS-CoV-2, the virus causing COVID-19, and all its tested variants. It also prevents the virus from mutating to resist the therapy
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Antibody-based immunotherapy was already shown to be effective against COVID-19 but faces two main obstacles: it needs to work against the circulating viral variants; it must prevent formation of new variants, that can rapidly ensue via a mechanism similar to that leading to antibiotic resistant bacteria. ....

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