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Pancreatitis drug blocks SARS-CoV-2 activators in the upper respiratory tract


Pancreatitis drug blocks SARS-CoV-2 activators in the upper respiratory tract
Pancreatitis drug Camostat inhibits new SARS-CoV-2 activators identified in the upper respiratory tract.
There are no therapeutics available that have been developed for COVID-19 treatment. Repurposing already available medication for COVID-19 therapy is an attractive option to shorten the road to treatment development.
The drug Camostat could be suitable. Camostat exerts antiviral activity by blocking the protease TMPRSS2, which is used by SARS-CoV-2 for entry into cells.
However, it was previously unknown whether SARS-CoV-2 can use TMPRSS2-related proteases for cell entry and whether these proteases can be blocked by Camostat. Moreover, it was unclear whether the metabolization of Camostat interferes with antiviral activity. ....

Markus Hoffmann , Danny Jonigk , Armin Braun , Emily Henderson , German Primate Center , Leibniz Institute For Primate Research , Leibniz Institute , Institute Of Pathology , Primate Research , Infection Biology Unit , Study First Author , Sars Cov 2 , மார்கஸ் ஹாஃப்மேன் , அர்மின் மூளை , எமிலி ஹென்டர்சன் , ஜெர்மன் ப்ரைமேட் மையம் , நிறுவனம் ஆஃப் நோயியல் , ப்ரைமேட் ஆராய்ச்சி , தொற்று உயிரியல் அலகு , படிப்பு முதல் நூலாசிரியர் ,