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High-resolution structures shed new light on receptor desensitisation


High-resolution structures of the archaerhodopsin-3 protein shed new light on receptor desensitisation
Crystals of AR3 observed under polarised light
For the first time, an international team of researchers has visualised the light-sensitive protein archaerhodopsin-3 (AR3) at unprecedented resolution using the I24 and B23 beamlines and supported by the Membrane Protein Laboratory (MPL)  at Diamond. The photoreceptor is expressed by
Halorubrum sodomense , an organism that grows in the Dead Sea, but is best known for its applications in optogenetics experiments, in which it is used to silence individual neurons and to detect changes in cell membrane voltage. These new structures open the way for the development of new tools and methodologies in the fields of neuroscience, cell biology and beyond. ....

United Kingdom , Anthony Watts , Danny Axford , Juan Francisco Bada , Isabel Moraes , Nature Communications , Protein Data Bank , National Physical Laboratory , Membrane Protein Laboratory , Dead Sea , Protein Data , Senior Beamline Scientist , ஒன்றுபட்டது கிஂக்டம் , அந்தோணி வாட்ஸ் , டேனி ஆக்ஸ்போர்டு , ஜுவான் பிரான்சிஸ்கோ பாட , இசபெல் மரஸ் , இயற்கை தகவல்தொடர்புகள் , ப்ரோடீந் தகவல்கள் வங்கி , தேசிய உடல் ஆய்வகம் , சவ்வு ப்ரோடீந் ஆய்வகம் , இறந்தவர் கடல் , ப்ரோடீந் தகவல்கள் ,