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Efficacy of a single low dose of esketamine after childbirth for mothers with symptoms of prenatal depression: randomised clinical trial

Objective To determine whether a single low dose of esketamine administered after childbirth reduces postpartum depression in mothers with prenatal depression.

Design Randomised, double blind, placebo controlled trial with two parallel arms.

Setting Five tertiary care hospitals in China, 19 June 2020 to 3 August 2022.

Participants 364 mothers aged ≥18 years who had at least mild prenatal depression as indicated by Edinburgh postnatal depression scale scores of ≥10 (range 0-30, with higher scores indicating worse depression) and who were admitted to hospital for delivery.

Interventions Participants were randomly assigned 1:1 to receive either 0.2 mg/kg esketamine or placebo infused intravenously over 40 minutes after childbirth once the umbilical cord had been clamped.

Main outcome measures The primary outcome was prevalence of a major depressive episode at 42 days post partum, diagnosed using the mini-international neuropsychiatric interview. Seco ....

Ming Jiang , Yuan Li , United States , Liang Chen , City Of , United Kingdom , Xin Zhong Chen , Tao Han , Danieli Sessler , Shan Wu Feng , Hui Ying Zhang , Li Xu , Dong Xin Wang , Fei Xue Wang , Shuo Wang , Chun Mei Deng , Xin Yu Sun , National Natural Science Foundation Of China , Zhejiang University , Drug Administration , American Society Of Anesthesiologists , National High Level Hospital Clinical Research Funding , University First Hospital , Mei Deng , Zhong Chen , Mei Yuan ,

New study demonstrates excellent prospective performance of HDAI's Risk Stratification Models across multiple data sources

/PRNewswire/ New research conducted by Health Data Analytics Institute (HDAI), in collaboration with researchers at the Cleveland Clinic, has been published. ....

United States , Richard Jordan , Erik Milster , Paulj Manberg , Carola Endicott , Danieli Sessler , Nassib Chamoun , Georgef Chamoun , Zhenyu Hong , Kamal Maheshwari , Scott Greenwald , Health Data Analytics Institute , Health Vision , American Society Of Anesthesiologists , Outcomes Research , Cleveland Clinic , American Society , Out Of Sample Validation , Risk Stratification Index , Using Commercial All Payer , All Payor Claims Datasets , Payer Claims , General Anesthesiology , Accountable Care Organizations , Extended Age Out Of Sample Validation , Using Commercial All Payor Claims ,

PROTECT Questions Hypothermia Prevention at Noncardiac Surgery

"There was absolutely no benefit, whatsoever, to aggressive warming," nor reduced risks for infection, transfusions, or readmission, said researchers, based on a rare, randomized trial of the issue. ....

United States , Danieli Sessler , Jamesb Mcclurken , Doylestown Health Physicians , American College Of Cardiology , Cleveland Clinic , American College , Breaking Clinical Trials , Myocardial Injury After Non Cardiac Surgery , Perioperative Cardiac Management , Laparoscopic Surgery , Clinical Research , Clinical Trials , Linical Studies , Medical Literature ,

Aggressively warming patients during surgery offers no benefit, study says

Patients kept at a body temperature of 37 C during major surgery had no fewer cardiac complications than patients kept at 35.5 C, according to data presented at the American College of Cardiology's 71st Annual Scientific Session. ....

Michael Cudahy , Danieli Sessler , Emily Henderson , Department Of Outcomes Research At Cleveland Clinic , American College Of Cardiology , American College , Annual Scientific , Outcomes Research , Cleveland Clinic ,

Aggressive warming during surgery does not reduce major complications: Study

Patients kept at a body temperature of 37 C during major surgery had no fewer cardiac complications than patients kept at 35.5 C, according to the American College of Cardiology s researchers. ....

Michael Cudahy , Danieli Sessler , Department Of Outcomes Research At Cleveland Clinic , American College Of Cardiology , American College , Outcomes Research , Cleveland Clinic , Ews India ,