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UVA Cancer Center discovers immunotherapy, could cure brain cancer forms

CAR T-cell immunotherapy has been successful in tackling blood cancers but not solid tumors.  ....

United States , Daniel Trey Lee , Cancer Center ,

Stem cell transplants offer long-term benefits for pediatric cancer patients receiving immunotherapy


Stem cell transplants offer long-term benefits for pediatric cancer patients receiving immunotherapy
Apr 1 2021
Children and young adults who receive CAR T-cell therapy for the most common childhood cancer - acute lymphoblastic leukemia - suffer remarkably fewer relapses and are far more likely to survive when the treatment is paired with a subsequent stem cell transplant, a new study finds.
Daniel Trey Lee is conducting pioneering clinical research in the battle against childhood cancer. Image Credit: UVA Health
The research, with an average follow up of nearly five years, suggests that stem cell transplants offer long-term benefits for young patients who receive the cutting-edge immunotherapy. CAR T-cell therapy results in complete remission in 60%-100% of patients initially, but the relapse rate is high. However, among those who received a stem cell transplant after CARs, the relapse rate was less than 10% two years later. ....

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