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Novel protein construct prevents lethal COVID-19 in mice

Novel protein construct prevents lethal COVID-19 in mice
Researchers in the United States have developed a novel protein that prevented lethal disease among mice infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).
The team engineered a soluble, short, and dimeric version of the native host cell receptor that is bound by a surface structure on SARS-CoV-2 called spike during the initial stage of the infection process.
The team – from the Feinberg School of Medicine in Chicago, the University of Chicago, and Northwestern University in Evanston – suspected that a soluble, truncated version of this membrane-bound receptor – called angiotensin-converting enzyme 2 (ACE2) – would serve as a decoy for SARS-CoV-2 spike binding and potentially neutralize infection. ....

United States , University Of Chicago , Daniel Batlle , Sally Robertson , Feinberg School Of Medicine , Northwestern University In Evanston , Feinberg School , Northwestern University , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , In Vitro , In Vivo , Mouse Model , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் சிகாகோ , சாலி ராபர்ட்சன் , ஃபைன்பெர்க் பள்ளி ஆஃப் மருந்து , வடமேற்கு பல்கலைக்கழகம் இல் எவன்ஸ்டன் , ஃபைன்பெர்க் பள்ளி , வடமேற்கு பல்கலைக்கழகம் , பிணைப்பு இன உறவு ,

New protein acts as trickster to neutralize COVID-19 infection in human kidney organoid

New protein acts as trickster to neutralize COVID-19 infection in human kidney organoid
Decoy protein intercepts spike of coronavirus. Virus prevented from infecting human cells. Protein may be a new way to treat and prevent COVID-19.
Northwestern Medicine scientists have developed a new protein that acts as a trickster to neutralize the COVID-19 infection in a human kidney organoid, a miniature organ made from stem cells in the lab.
The protein is a variant of ACE2 (angiotensin-converting enzyme-2), the receptor the coronavirus uses to enter and infect human cells. The modified protein intercepts the S spike of the coronavirus and fools it into binding to it rather than the real ACE2 receptor in cell membranes. ....

United States , Daniel Batlle , Jan Wysocki , Emily Henderson , Journal Of The American Society Nephrology , Northwestern University , Northwestern University Feinberg School Of Medicine , Study Lead Author , Northwestern Medicine , Northwestern University Feinberg School , American Society , Del Greco , Levin Professor , Investigational New Drug , ஒன்றுபட்டது மாநிலங்களில் , ஜான் விசொக்கி , எமிலி ஹென்டர்சன் , இதழ் ஆஃப் தி அமெரிக்கன் சமூகம் நெப்ராலஜி , வடமேற்கு பல்கலைக்கழகம் , வடமேற்கு பல்கலைக்கழகம் ஃபைன்பெர்க் பள்ளி ஆஃப் மருந்து , படிப்பு வழி நடத்து நூலாசிரியர் , வடமேற்கு மருந்து , வடமேற்கு பல்கலைக்கழகம் ஃபைன்பெர்க் பள்ளி , அமெரிக்கன் சமூகம் , டெல் க்ரெகொ , லெவின் ப்ரொஃபெஸர் ,

New protein developed to neutralize COVID-19 in human kidney

CHICAGO, Feb. 2 (Xinhua) Northwestern Medicine scientists have developed a new protein that acts as a trickster to neutralize the COVID-19 infection in a human kidney organoid, a miniature organ made from stem cells in the lab.
The protein is a variant of ACE2, angiotensin converting enzyme-2, the receptor the coronavirus uses to enter and infect human cells. The modified protein intercepts the S spike of the coronavirus and fools it into binding to it rather than the real ACE2 receptor in cell membranes.
The researchers have studied ACE2 for many years as part of a potential treatment for kidney disease. They have have bioengineered novel ACE2 variants licensed to Northwestern University (NU) which they believe can be adapted for COVID-19 therapy by intercepting the coronavirus and preventing it from attaching to the natural ACE2 receptor in the membrane of the cell. ....

Northwestern University , United States , Daniel Batlle , Journal Of The American Society Nephrology , Nu Feinberg School Of Medicine , Northwestern Medicine , Investigational New Drug , American Society , Northwestern Memorial Healthcare , வடமேற்கு பல்கலைக்கழகம் , ஒன்றுபட்டது மாநிலங்களில் , இதழ் ஆஃப் தி அமெரிக்கன் சமூகம் நெப்ராலஜி , னு ஃபைன்பெர்க் பள்ளி ஆஃப் மருந்து , வடமேற்கு மருந்து , அமெரிக்கன் சமூகம் , வடமேற்கு நினைவகம் சுகாதாரம் ,

New protein developed to neutralize COVID-19 in human kidney - Life & Culture News

2021-02-02 21:35:53 GMT2021-02-03 05:35:53(Beijing Time) Xinhua English

CHICAGO, Feb. 2 (Xinhua) Northwestern Medicine scientists have developed a new protein that acts as a trickster to neutralize the COVID-19 infection in a human kidney organoid, a miniature organ made from stem cells in the lab.
The protein is a variant of ACE2, angiotensin converting enzyme-2, the receptor the coronavirus uses to enter and infect human cells. The modified protein intercepts the S spike of the coronavirus and fools it into binding to it rather than the real ACE2 receptor in cell membranes.
The researchers have studied ACE2 for many years as part of a potential treatment for kidney disease. They have have bioengineered novel ACE2 variants licensed to Northwestern University (NU) which they believe can be adapted for COVID-19 therapy by intercepting the coronavirus and preventing it from attaching to the natural ACE2 receptor in the membrane of the cell. ....

Northwestern University , United States , Daniel Batlle , Journal Of The American Society Nephrology , Nu Feinberg School Of Medicine , Northwestern Medicine , Investigational New Drug , American Society , Northwestern Memorial Healthcare , வடமேற்கு பல்கலைக்கழகம் , ஒன்றுபட்டது மாநிலங்களில் , இதழ் ஆஃப் தி அமெரிக்கன் சமூகம் நெப்ராலஜி , னு ஃபைன்பெர்க் பள்ளி ஆஃப் மருந்து , வடமேற்கு மருந்து , அமெரிக்கன் சமூகம் , வடமேற்கு நினைவகம் சுகாதாரம் ,