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'Triple G' Agonist Hits New Weight-Loss Heights

An editorial on phase 2 results from treating people with obesity or overweight but not diabetes with retatrutide, a triple hormone–receptor agonist, calls the weight loss achieved "unprecedented." ....

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'This raises the bar': Phase 2 data show 24% weight loss with triple-agonist retatrutide

SAN DIEGO — Adults with obesity who received the highest dose of a once-weekly injection of retatrutide lost an average of 24.2% of their body weight at 48 weeks compared with placebo, data from a phase 2 study show.
With the highest 12 mg dose of retatrutide (Eli Lilly) — an investigational GLP-1, glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptor agonist ....

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Triple Agonist Retatrutide Hits New Weight-Loss Highs

Treatment with retatrutide, an agonist to GLP-1, GIP, and glucagon receptors in one molecule, was associated with unprecedented drops in weight from people with or without type 2 diabetes in a pair of early studies. ....

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ONWARDS 1: Benefits of once-weekly vs. daily insulin sustained through 78 weeks

SAN DIEGO — Adults with type 2 diabetes naive to insulin therapy saw a long-term reduction in HbA1c and superior time in the recommended glucose range with once-weekly insulin icodec compared with daily insulin glargine, data show.ONWARDS 1, the longest trial in the ONWARDS development program for insulin icodec (Novo Nordisk), showed that the novel weekly insulin regimen facilitated the ....

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Miracle weight-loss injection is nearly TWICE as good as others

A US study saw around 400 overweight and obese people in their fifties given an injection that lowers their food intake and blood sugar levels. ....

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