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USC study reveals potential new treatment target in the fight against COVID-19


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IMAGE: Images of cells showing close proximity (yellow) of GRP78 (green) with Spike protein of SARS-Cov-2 (red) (left panels) and ACE2 (red) (right panels).
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Credit: Lead author Anthony Carlos, PhD
The swift development of vaccines has provided a vital tool to combat the spread of the deadly SARS-CoV-2 virus, but challenges to reaching herd immunity posed by the rise of new mutations and the inability of immunosuppressed people to develop an effective immune response following vaccination point to a need for additional solutions to maximize protection.
A new USC study published in the
Journal of Biological Chemistry reveals how therapies targeting a molecular chaperone called GRP78 might offer additional protection against COVID-19 and other coronaviruses that emerge in the future. ....

Anthony Carlos , Larry Freeman , Amys Lee , Keigo Machida , Pu Zhang , Chun Chih Tseng , Richard Van Krieken , Parkash Gill , Iwei Yeh , National Institute Of Health , Keck School Of Medicine , Wm Keck Foundation , Biological Chemistry , Keck School , Larry Freeman Chair , Da Wei Yeh , National Institute , Keck Foundation , Cell Biology , Pharmaceutical Sciences , Medicine Health , Infectious Emerging Diseases , Pharmaceutical Science , Public Health , லாரி ஃப்ரீமேன் , பு ஜாங் ,