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Getting control of COVID-19 will take more than widespread vaccination; it will also require better understanding of why the disease causes no apparent symptoms in some people but leads to rapid multi-organ failure and death in others, as well as better insight into what treatments work best and for which patients.
To meet this unprecedented challenge, researchers at Massachusetts General Hospital (MGH), in collaboration with investigators from Brigham and Women’s Hospital and the University of Cyprus, have created a mathematical model based on biology that incorporates information about the known infectious machinery of SARS-CoV-2, the virus that causes COVID-19, and about the potential mechanisms of action of various treatments that have been tested in patients with COVID-19.  ....

United States , Mohammad Reza Nikmaneshi , Edwinl Steele , Sayon Dutta , Triantafyllos Stylianopoulos , Chrysovalantis Voutouri , Rakeshk Jain , Lancel Munn , C Corey Hardin , Ashish Verma , Melinj Khandekar , Ankitb Patel , Jane Trust Foundation , National Institutes Of Health , Harvard Medical School , National Foundation For Cancer Research , Sharif University Of Technology , Proceedings Of The National Academy Sciences , Harvard Ludwig Cancer Center , American Medical Research Foundation , University Of Cyprus , European Research Council , Department Of Radiation Oncology , Innovation Foundation , Cyprus Research , Massachusetts General Hospital ,