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Kintara Therapeutics : TuHURA Biosciences to Present Its IFx-2.0 Personalized Cancer Vaccine Clinical Trial Results at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting - Form 8-K

TuHURA Biosciences to Present Its IFx-2.0 Personalized Cancer Vaccine Clinical Trial Results at the 2024 American Society of Clinical Oncology Annual Meeting

TAMPA, FL&SAN. ....

United States , San Diego , Jenene Thomas , Andrew Brohl , Roberte Hoffman , Tuhura Biosciences Inc , H Lee Moffitt Cancer Center , American Society Of Clinical Oncology , Kintara Therapeutics Inc , Exchange Commission , Research Institute , Present Its , Cancer Vaccine Clinical Trial Results , Clinical Oncology , Annual Meeting , Merkel Cell Carcinoma , Cutaneous Squamous Cell Carcinoma , Moffitt Cancer Center , Skin Cancers , Kintara Therapeutics , Antibody Drug Conjugates , Nasdaq Capital Market , Merkel Cell , Myeloid Derived Suppressor Cells , Information About , Proposed Merger ,

TuHURA Biosciences to Present Its IFx-2.0 Personalized Cancer Vaccine ...

TuHURA Biosciences to Present Its IFx-2.0 Personalized Cancer Vaccine . ....

United States , San Diego , Andrew Brohl , News Network , H Lee Moffitt Cancer Center , Tuhura Biosciences Inc , Exchange Commission , Kintara Therapeutics Inc , Research Institute Session Title , Merkel Cell Carcinoma , Cutaneous Squamous Cell Carcinoma , Moffitt Cancer Center , Skin Cancers Session Date , Kintara Therapeutics , Antibody Drug Conjugates , Nasdaq Capital Market , Merkel Cell , Myeloid Derived Suppressor Cells , Information About , Proposed Merger , Registration Statement ,

TuHURA Biosciences to Present Its IFx-2.0 Personalized Cancer Vaccine Clinical Trial Results at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting

TuHURA Biosciences to Present Its IFx-2.0 Personalized Cancer Vaccine Clinical Trial Results at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting
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United States , San Diego , Jenene Thomas , Roberte Hoffman , Andrew Brohl , Exchange Commission , Morphogenesis Inc , Kintara Therapeutics Inc , H Lee Moffitt Cancer Center , Research Institute , Tuhura Biosciences Inc , Merkel Cell Carcinoma , Cutaneous Squamous Cell Carcinoma , Moffitt Cancer Center , Kintara Therapeutics , Antibody Drug Conjugates , Nasdaq Capital Market , Merkel Cell , Myeloid Derived Suppressor Cells , Securities Act , Information About , Proposed Merger , Registration Statement , Annual Report , Private Securities Litigation Reform Act , Merger Agreement ,

Diagnosis and Prognosis of Locally Advanced Cutaneous Squamous Cell Carcinoma

Nikhil I. Khushalani, MD, of Moffitt Cancer Center, discusses the diagnosis and prognosis of patients with locally advanced cutaneous squamous cell carcinoma. ....

Locally Advanced , Metastatic Cutaneous Squamous Cell Carcinoma , Locally Advanced Cutaneous Squamous Cell , Cutaneous Squamous Cell Carcinoma , Sun Exposure , Dvanced Cscc , Treatment Options , Pd 1 Inhibitors , Iv Infusions , Long Term Disease Control ,

"PIK Your Poison: The Effects of Combining PI3K and CDK Inhibitors agai" by Jay R. Perry, Benjamin Genenger et al.

Cutaneous squamous cell carcinoma (cSCC) is a very common skin malignancy with poor prognosis for patients with locally advanced or metastatic cSCC (mcSCC). PI3K/AKT/mTOR and cell cycle signalling pathways are often dysregulated in mcSCC. A combination drug approach has been theorised to overcome the underwhelming clinical performance of targeted inhibitors as single agents. This study investigates the potential of targeted inhibition of the p110α−subunit of PI3K with PIK-75 or BGT226 (P13Ki), and of CDK1/2/5/9 with dinaciclib (CDKi) as single agents and in combination. The patient−derived mcSCC cell lines, UW-CSCC1 and UW-CSCC2, were used to assess cell viability, migration, cell signalling, cell cycle distribution, and apoptosis. PIK-75, BGT226, and dinaciclib exhibited strong cytotoxic potency as single agents. Notably, the non-malignant HaCaT cell line was unaffected. In 2D cultures, PIK-75 synergistically enhanced the cytotoxic effects of dinaciclib in UW-CSCC2, but not UW-CS ....

Cdk1 2 5 9 , Combination Therapy , Cutaneous Squamous Cell Carcinoma , Cyclin Dependent Kinase , Hosphoinositid 3 Kinase , Ik 75 , Targeted Therapy ,