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Frontiers | Crystal structures of glycoprotein D of equine alphaherpesviruses reveal potential binding sites to the entry receptor MHC-I

Cell entry of most alphaherpesviruses is mediated by the binding of glycoprotein D (gD) to different cell surface receptors. Equine herpesvirus type 1 (EHV-1) and EHV-4 gDs interact with equine major histocompatibility complex I (MHC-I) to initiate entry into equine cells. We have characterized the gD-MHC-I interaction by solving the crystal structures of EHV-1 and EHV-4 gDs (gD1, gD4), performing protein-protein docking simulations, surface plasmon resonance (SPR) analysis, and biological assays. The structures of gD1 and gD4 revealed the existence of a common V-set immunoglobulin-like (IgV-like) core comparable to those of other gD homologs. Molecular modeling yielded plausible binding hypotheses and identified key residues (F213 and D261) that are important for virus binding. Altering the key residues resulted in impaired virus growth in cells, which highlights the important role of these residues in the gD-MHC-I interaction. Taken together, our results add to our understanding of t ....

Mecklenburg Vorpommern , United States , New York , Uppsala Lan , United Kingdom , Baden Wüberg , New Zealand General , New Zealand , San Diego , Richmond Upon Thames , City Of , Nordrhein Westfalen , Deutsche Forschungsgemeinschaft , Applichem Gm , Cytexpert Beckman Coulter , Los Alamos , Clustalomega Sievers , Eva Crosas , Biochom Gm , Santa Barbara , Bruker Daltonics , Santa Clara , Zeiss Axiovert , Molekulare Pharmakologie , David Machalz , Molprobity Williams ,

Inside the Race To Find Earth's Oldest Ice

Inside the Race To Find Earth’s Oldest Ice. A global race is on to drill for the oldest known layers of Antarctic ice so researchers can peer back in time to a warmer climate to better understand the planet’s hotter future Deep in Antarctica’s. ....

Allan Hills , United States , John Higgins , Peter Neff , Sarah Shackleton , Christo Buizert , Princeton University , Oregon State University , Oldest Ice Exploration , Core Facility , South Pole , Pulitzer Center ,