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E-Mail IMAGE: Induction of Yamanaka factors (OKSM) in muscle fibers increases the number of myogenic progenitors. Top, control; bottom, treatment. Red-pink color is Pax7, a muscle stem-cell marker. Blue indicates muscle nuclei.. view more Credit: Salk Institute LA JOLLA (May 25, 2021) One of the many effects of aging is loss of muscle mass, which contributes to disability in older people. To counter this loss, scientists at the Salk Institute are studying ways to accelerate the regeneration of muscle tissue, using a combination of molecular compounds that are commonly used in stem-cell research. In a study published on May 25, 2021, in Nature Communications, the investigators showed that using these compounds increased the regeneration of muscle cells in mice by activating the precursors of muscle cells, called myogenic progenitors. Although more work is needed before this approach can be applied in humans, the research provides insight into t ....
Credit: Salk Institute LA JOLLA (April 15, 2021) The ability to grow the cells of one species within an organism of a different species offers scientists a powerful tool for research and medicine. It s an approach that could advance our understanding of early human development, disease onset and progression and aging; provide innovative platforms for drug evaluation; and address the critical need for transplantable organs. Yet developing such capabilities has been a formidable challenge. Researchers led by Salk Professor Juan Carlos Izpisua Belmonte have now come one step closer toward this goal by demonstrating a new integration of human cells into animal tissue. Published in the journal ....