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Bugs Bite At best, bug bites hurt and make you itch. At worst, you can contract fevers, viruses (Zika and West Nile), or Lyme disease. We think you’ll agree bite prevention is a must-pack for a variety of outdoor activities. Defending against these bites takes more than a one-size-fits-all approach, though. Things to keep in mind with the spray include which insects you want to repel, and how long you need it to last. The heavyweight ingredient in bug sprays is DEET. It’s an active ingredient recommended by the CDCto repel disease-carrying insects. DEET is proven to ward off insects, and when you’re in the thick of it, you’ll be grateful for it. Other powerful ingredients include permethrin and picaridin. Permethrin is used solely on clothes and gear not skin, and picaridin is an odorless, non-greasy option that you can use on skin or gear and apparel. ....