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ST-segment myocardial infarction (STEMI) in COVID-19 patients was linked to a higher burden of neutrophil extracellular traps (NETs) in a case series suggesting an important role in pathogenesis of coronary thrombosis from the infection.
These structures webs spun by neutrophils to snag pathogens turned up in coronary thrombi of all five COVID-positive STEMI patients where thrombus aspiration was done in the cath lab of one Spanish academic center.
The density of NETs was much higher in these samples than in a historical STEMI series of 50 patients, of whom 68% had NETS detected in coronary thrombus aspirates: a median of 61% versus 19% (