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Early Release - Impact of Human Papillomavirus Vaccination, Rwanda and Bhutan - Volume 27, Number 1—January 2021 - Emerging Infectious Diseases journal


Abstract
Rwanda and Bhutan, 2 low- and middle-income countries, implemented primarily school-based national human papillomavirus (HPV) vaccination in 2011 (Rwanda) and 2010 (Bhutan). We estimated vaccination effectiveness through urine-based HPV prevalence surveys in schools in 2013–2014 and 2017. In Rwanda, 912 participants from baseline surveys and 1,087 from repeat surveys were included, and in Bhutan, 973 participants from baseline surveys and 909 from repeat surveys were included. The overall effectiveness against vaccine-targeted HPV types (i.e., HPV-6/11/16/18) was 78% (95% CI 51%–90%) in Rwanda, and 88% (6%–99%) in Bhutan and against other α-9 types was 58% (21–78) in Rwanda and 63% (27–82) in Bhutan. No effect against other HPV types was detectable. Prevalence of vaccine-targeted HPV types decreased significantly, as well as that of other α-9 types, suggesting cross-protection. These findings provide direct evidence from low- and middle-income countries of ....

United States , Noord Holland , Colli Pee , International Agency For Research On Cancer , Amsterdam University Medical Center , World Health Organization , University Of Antwerp , Ethics Committee , Centre For The Evaluation Of Vaccination , International Agency , Nyarugenge District , Vrije Universiteit Amsterdam , Appendix Figure , Appendix Table , ஒன்றுபட்டது மாநிலங்களில் , நூற்த் ஹாலண்ட் , கோலி சிறுநீர் கழித்தல் , ஆம்ஸ்டர்டாம் பல்கலைக்கழகம் மருத்துவ மையம் , உலகம் ஆரோக்கியம் ஆர்கநைஸேஶந் , பல்கலைக்கழகம் ஆஃப் ஆண்ட்வெர்ப் , நெறிமுறைகள் குழு , மையம் க்கு தி மதிப்பீடு ஆஃப் தடுப்பூசி , பின் இணைப்பு எண்ணிக்கை , பின் இணைப்பு மேசை ,