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IMAGE: Pictured L-R: Caitlin Brandle, research assistant, Dr. Gang Zhou, Timothy Kim, undergraduate student, Nada S. Aboelella, PhD, graduate student, Dr. Zhi-Chun Ding, assistant professor view more
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Cancer immunotherapy using designer immune cells has revolutionized cancer treatment in recent years. In this type of therapy, T cells, a type of white blood cell, are collected from a patient s blood and subjected to genetic engineering to produce T cells carrying a synthetic molecule termed chimeric antigen receptor (CAR) that is designed to enable T cells to recognize and destroy cancer cells. Then these genetically modified CAR T cells are expanded to large quantity and infused back to the patient.
Study shows how STAT5 optimizes function of CD4+ T cells to drive antitumor immunity
Cancer immunotherapy using designer immune cells has revolutionized cancer treatment in recent years. In this type of therapy, T cells, a type of white blood cell, are collected from a patient s blood and subjected to genetic engineering to produce T cells carrying a synthetic molecule termed chimeric antigen receptor (CAR) that is designed to enable T cells to recognize and destroy cancer cells.
Then these genetically modified CAR T cells are expanded to large quantities and infused back to the patient.
CAR T cell-based immunotherapies have seen remarkable outcomes in some patients with certain types of cancer, but more work is needed to improve the persistence and function of CAR T cells so that more patients can benefit from this type of therapy.