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Acurx's ibezapolstat posts positive phase II data but stock slips

Acurx Pharmaceuticals Inc. continues to post positive data for its lead candidate ibezapolstat but that didn’t stop the stock from tumbling. The antibiotic outperformed vancomycin in a phase IIb study treating Clostridioides difficile infection (CDI). Vancomycin is a standard of care in the indication. Ibezapolstat eradicated fecal CDI at day 3 in 15 of 16 patients compared to vancomycin, which eradicated fecal CDI in 10 of 14 patients. ....

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Common Hospital-Administered Antibiotics Linked to C Difficile, Adverse Drug Reactions

Ciprofloxacin, ceftriaxone, and piperacillin/tazobactam showed the greatest associations with adverse drug reaction case reports related to C difficile. ....

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Black Patients Receive Less C Diff Tests Despite Similar Positivity Rates to White Patients

A retrospective cohort study of inpatient encounters from 3 hospitals in the Duke University Health System showed greater rates of testing among White patients compared to Black and NWNB patients. ....

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Phase 1 Trial Demonstrates Safety, Tolerability of Autologous FMT

Results showed autologous FMT was safe and well-tolerated but did not affect time to normalized intestinal habits compared to placebo. ....

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Antidepressant Use Linked to Increased Risk of Hospital-Onset C Diff

Use of mirtazapine, nortriptyline, and trazodone among hospitalized patients was associated with a greater risk of CDI. ....

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