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International team identifies 127 glaucoma genes in largest study of its kind

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In the largest genome-wide association study of glaucoma comparing the genes of 34,179 people with the disease to 349,321 control subjects, an international consortium of researchers identified 44 new gene loci and confirmed 83 previously reported loci linked to glaucoma. Loci are considered genetic street addresses, denoting a specific location on a gene.
The study s authors hope the identification of these genes will lead to new treatment targets for this incurable eye disease that is a leading cause of blindness worldwide.
These new findings come out of the highest-powered genome-wide association study of glaucoma to date, and show the power of team science and using big data to answer questions when research groups around the world join forces, said co-senior study author Janey L. Wiggs, MD, PhD, Associate Chief of Ophthalmology Clinical Research at Mass Eye and Ear, and the Paul Austin Chandler Professor of Ophthalmology and Vice Chair of Clinical Re ....

United States , United Kingdom , South Africa , Ayelletv Segr , Puya Gharahkhani , Stuart Macgregor , Janeyl Wiggs , Paul Austin Chandler , Ocular Genomics Institute At Harvard Medical School , Nature Communications , National Institutes Of Health , Harvard Medical School , National Academy Of Medicine , Berghofer Medical Research Institute , National Eye Institute , Clinical Research At Harvard Medical School , Ophthalmology Clinical Research At Mass Eye , Ocular Genomics Institute At Harvard Ophthalmology , Associate Chief , Ophthalmology Clinical Research , Mass Eye , Paul Austin Chandler Professor , Vice Chair , Clinical Research , Harvard Medical , Associate Director ,

International Team Identifies 127 Glaucoma Genes in Largest Study of Its Kind

International Team Identifies 127 Glaucoma Genes in Largest Study of Its Kind
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United States , United Kingdom , South Africa , Ayelletv Segr , Puya Gharahkhani , Stuart Macgregor , Janeyl Wiggs , Paul Austin Chandler , Ocular Genomics Institute At Harvard Medical School , Nature Communications , National Institutes Of Health , Harvard Medical School , National Academy Of Medicine , Berghofer Medical Research Institute , National Eye Institute , Clinical Research At Harvard Medical School , Ophthalmology Clinical Research At Mass Eye , Ocular Genomics Institute At Harvard Ophthalmology , Associate Chief , Ophthalmology Clinical Research , Mass Eye , Paul Austin Chandler Professor , Vice Chair , Clinical Research , Harvard Medical , Associate Director ,