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[Full text] HDAC6 regulates the activation of M1 macrophages

Yao Wang,
Qian Chen, Fangzhou Jiao, Chunxia Shi, Maohua Pei, Luwen Wang, Zuojiong Gong
Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China
These authors contributed equally to this work
Correspondence: Zuojiong Gong; Luwen Wang
Department of Infectious Diseases, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, People’s Republic of China
Background: The glycolysis pathway of M1 macrophages is a key factor affecting the inflammatory response. The aim of this article is to investigate the role of histone deacetylase 6 (HDAC6) in the M1 macrophage glycolysis pathway during acute liver failure (ALF).
Methodology: Targeted metabolomics for quantitative analysis of energy metabolites technology was used to detect the characteristics of energy metabolism for 8 ALF patients and 8 normal volunteers. The ALF mice model was intervened with HDAC6 inhibitor ACY-1215. iTRAQ/TMT ....

United States , Eteläuomen Läi , United Kingdom , D Galactosamined Gal , Abbexa Cambridge , Committee Of Renmin Hospital Wuhan University , Mice Group , Abbott Co , Cell Signaling Technology Danvers , Type Culture Collection Wuhan University , Energy Enzymes , Renmin Hospital Of Wuhan University , China Center , National Institutes Of Health , Drug Administration , Energy Metabolite Examination , Department Of Infectious Diseases , Hubei Animal Experimental Center Wuhan , Measurement Of Energy Metabolites , Energy Metabolite , Ethics Committee , Renmin Hospital , Infectious Diseases , Wuhan University , Clinical Practical Guidelines , Grand Island ,