Background
High-grade B-cell lymphomas (HGBLs), with c-Myc, Bcl2, and/or Bcl6 rearrangement, are aggressive neoplasms with poor clinical outcomes. Cyclin D1 is a proto-oncogene that is generally expressed by mantle cell lymphoma, its variants, and many other neoplasms.
Aim
The aim of this study is to investigate the expression and frequency of cyclin D1 in HGBL and its association with double expressor and triple expressor lymphomas. A few pieces of research have been reported on the expression of cyclin D1 in triple-hit lymphoma, renaming it quadruple-hit lymphoma. In the present study, we also used immunohistochemical (IHC) stains to look at the expression of cyclin D1 in double expressor and triple expressor.
Methodology
This is a cross-sectional descriptive study involving 60 cases, including both double and triple expressors, diagnosed by using hematoxylin and eosin (H&E) staining with subsequent IHC stains. We analyzed the expression of cyclin D1 in double expressor
Background
The term triple-negative breast cancer (TNBC) refers to a particular class of aggressive, poorly differentiated neoplasms that show the absence of estrogen (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER2) antibodies. SOX10 (SRY-related HMG-box 10) is a nuclear transcription factor that is commonly used to identify cancers of neural origin, but it has recently been linked to TNBC. The purpose of this study is to determine SOX10 expression in TNBC, its association with tumor grade for molecular categorization, and to determine the diagnostic significance of SOX10 in TNBC at the metastatic site in the case of an unknown primary.
Methodology
SOX10 was used to stain a tissue microarray of 100 patients. According to the tumor grade, SOX10 staining was classified as negative (<1%), patchy (1-10%), focal (10-70%), and diffuse (70-100%). SPSS version 22 (IBM Corp., Armonk, NY, USA) software was used to conduct the statistical analysis.
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By Our correspondents
ISLAMABAD/LAHORE: The national tally on Wednesday of total active COVID-19 cases recorded 84,480 with 4,113 more people tested positive for the deadly virus and 5,665 people recovered from the disease during the last 24 hours. While, the Punjab government have decided to enforce a complete lockdown in the provinces from May 8.
According to the latest update issued by the National Command and Operation Centre (NCOC), one hundred and nineteen corona patients have died during past 24 hours, 106 of whom were under treatment in hospital and 13 out of the hospital in their respective quarantines or homes,.
During the past 24 hours, most of the deaths have occurred in the Punjab followed by Khyber Pakhtunkhwa. Out of the total 119 deaths occurred in the last 24 hours 38 of them had died who were under treatment on ventilators.