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Johns Hopkins study shows mother's diet may boost immune systems of premature infants


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IMAGE: Photomicrographs of tissue taken from the intestines of infant mice and grown in culture as intestinal organoids, or enteroids, that are basically mini-intestines for research. The enteroids shown are from.
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Credit: C. Sodhi, W. Fulton and D. Hackam, Johns Hopkins Medicine
Medical researchers have long understood that a pregnant mother s diet has a profound impact on her developing fetus s immune system and that babies especially those born prematurely who are fed breast milk have a more robust ability to fight disease, suggesting that even after childbirth, a mother s diet matters. However, the biological mechanisms underlying these connections have remained unclear. ....

Bruxelles Capitale , Qinjie Zhou , David Hackam , William Fulton , Peng Lu , Peter Wipf , Sanxia Wang , Maame Sampah , Thomas Prindle Jr , Hongpeng Jia , Mark Kovler , Yukihiro Yamaguchi , Chhinder Sodhi , Andres Gonzalez Salazar , Johns Hopkins Children Center , Nature Communications , Garrett Fund For Surgical Research , University Of Pittsburgh , National Institutes Of Health , Drug Administration , Johns Hopkins University School Of Medicine , Johns Hopkins Medicine , Johns Hopkins Children , Johns Hopkins University School , Thomas Prindle , National Institutes ,

Mouse study finds link between gut disease and brain injury in premature infants


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IMAGE: Photomicrographs demonstrating the impact of T lymphocytes (T cells) associated with the intestinal disease necrotizing enterocolitis (NEC) on myelin a fatty material that surrounds and protects nerve cells .
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Credit: C. Zhou, C. Sodhi and D. J. Hackam, Johns Hopkins Medicine
Physicians have long known that necrotizing enterocolitis (NEC), a potentially lethal inflammatory condition that destroys a premature infant s intestinal lining, is often connected to the development of severe brain injury in those infants who survive. However, the means by which the diseased intestine communicates its devastation to the newborn brain has remained largely unknown. ....

Qinjie Zhou , David Hackam , Meaghan Morris , William Fulton , Peng Lu , David Pamies , Thomas Prindle , Sanxia Wang , Hongpeng Jia , Yukihiro Yamaguchi , Chhinder Sodhi , Johns Hopkins Children Center , National Institutes Of Health , University Of Minnesota , University Of Lausanne , Johns Hopkins University School Of Medicine , Fred Hutchinson Cancer Research Center , Johns Hopkins Medicine , Science Translational , Johns Hopkins Children , Johns Hopkins University School , Liam Chen , National Institutes , மேஅகங் மோரிஸ் , வில்லியம் ஃபுல்டன் , பெங் லு ,