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A novel approach to suppress the growth of glioblastoma cells


A novel approach to suppress the growth of glioblastoma cells
Inhibiting a key enzyme that controls a large network of proteins important in cell division and growth paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing.
Researchers at Princess Margaret Cancer Centre, the Hospital for Sick Children (SickKids) and University of Toronto, showed that chemically inhibiting the enzyme PRMT5 can suppress the growth of glioblastoma cells.
The inhibition of PRMT5 led to cell senescence, similar to what happens to cells during aging when cells lose the ability to divide and grow. Cellular senescence can also be a powerful tumor suppression mechanism, stopping the unrelenting division of cancer cells. ....

Patty Sachamitr , Panagiotis Prinos , Cheryl Arrowsmith , Peter Dirks , Emily Henderson , University Of Toronto , Researchers At Princess Margaret Cancer Centre , Senior Research , Cancer Canada Dream Team , International Structural Genomics Consortium , Structural Genomics Consortium , Nature Communications On , Princess Margaret Cancer Centre , Sick Children , Nature Communications , Postdoctoral Fellow , Senior Research Associate , Senior Scientist Cheryl Arrowsmith , Princess Margaret , Senior Scientist , Neurosurgeon Peter Dirks , Brain Cancer , Cell Division , Stem Cells , செரில் அம்புக்குறி , பீட்டர் டர்க்ஸ் ,