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Emulating target trials using observational data

An application to estimating mortality of delays in appropriate antibiotic treatment and accounting for time-varying confounding and immortal time biases

Delays in treating bacteraemias with antibiotics to which the causative organism is susceptible are expected to adversely affect patient outcomes. However, the extent of the impact remains to be elucidated. This cannot ethically be addressed in a randomised trial. ....

Mahidol University , Mahidol Oxford Tropical Medicine Research Unit , Cherry Lim , Tropical Medicine ,

Smart locks: Convenience comes with security doubts

Smart locks: Convenience comes with security doubts
© Getty Images
Smart locks are becoming more common
For Candace Nelson, finding out about smart locks from a friend really was a game changer .
People like her, who live with Obsessive Compulsive Disorder (OCD), often feel a need to perform routines like washing their hands, counting things or checking a door is locked.
I have quite a few times nearly made it to work and couldn t remember if I locked the door, so I d turn around, she says.
On other occasions she has driven for an hour before turning back. My brain will not stop until I know for sure, explains Miss Nelson, who works for the Girl Scouts in Charleston, West Virginia. ....

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