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Scientists Pinpoint Structure of Antifungal, Challenge Binding Mechanism

Nearly seventy years after the discovery of Amphotericin B, scientists are still learning from this enigmatic drug. New results challenge a long-standing paradigm for the drug's mechanism of action and suggest new avenues for drug development. ....

Taras Pogorelov , Martin Burke , National Institutes Of Health , Morgridge Institute For Research , University Of Illinois At Urbana Champaign , National Magnetic Resonance Facility At Madison , National Institutes , Chad Rienstra , Morgridge Institute , Nature Structural , Molecular Biology , National Magnetic Resonance Facility ,