Polar Effects in Hydrogen Atom Transfer Reactions from a Proton-Coupled Electron Transfer (PCET) Perspective: Abstractions from Toluenes acs.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from acs.org Daily Mail and Mail on Sunday newspapers.
The use of short flashes of X-ray light brings scientists one big step closer toward developing better catalysts to transform the greenhouse gas methane into a less harmful chemical. The result, p .
Due to the prevalence of the trifluoromethyl group (CF3) in high-value organic compounds, there is a constant demand for more selective, efficient and economical trifluoromethylation strategies. In this report we present detailed experimental and computational investigations into the use of cheap and atom-economical CF3I in transition metal catalyzed trifluoromethylation. The mechanistic insight gained allowed novel C−H trifluoromethylation processes to be developed, using both palladium and nickel catalysis. The reported methodology is remarkably selective for C−H trifluoromethylation, with substituents such as amino, nitro, bromo and aldehydes tolerated. Our experimental and computational studies suggest that radical species are not involved, and that the key C−H activation step is facilitated by an unusual difluorocarbene intermediate. Importantly, arylCF3 formation occurs through unique arylCF2-F based reductive elimination, likely from Pd(II)/Ni(II) but potentially through o